Various Studies

Research and studies conducted throughout the world by eminent scientists have revealed the wholesome goodness and the natural healing capacity, of the miraculous non-toxic Stevia herb. A large number of tests that were conducted in determining the safety of Stevia have shown that this phenomenal herb controls diabetes by maintaining the blood glucose levels. Ideal for use by diabetics, it diminishes hypertension and is non- carcinogenic (does not result in Cancer). Apart from ensuring the enhancement of overall bodily functions and

health, Stevia and the pure extracts that are derived from Stevia assist in losing weight. Over 150 elaborate laboratory tests have been conducted on Stevia to understand the benefits and the effects of this natural sweetener.

1. Stevia for Hypertension:

Conclusion: This study shows that oral Stevioside is a well-tolerated and effective modality that may be considered as an alternative or supplementary therapy for patients with hypertension.

http://www.Steviainfo.com/research_articles/Chan-et-al(2000).pdf

2. Antihyperglycemic Effects of Stevioside in Type 2 Diabetic Subjects 2004

Conclusion: Stevioside reduces postprandial blood glucose levels in Type 2 Diabetic patients, indicating beneficial effects on the glucose metabolism. Stevioside may be advantageous in the treatment of Type 2 Diabetes.

http://www.steviainfo.com/research_articles/Gregersen-et-al(2004).pdf

3. Antihyperglycemic and Blood Pressure-Reducing Effects of Stevioside in the Diabetic Goto-Kakizaki Rat 2003 Conclusion: Stevioside enjoys a dual effect by acting as an anti-hyperglycaemic and a blood pressure-lowering substance; effects that may have therapeutic potential in the treatment of type 2 diabetes and the metabolic syndrome.

http://www.steviainfo.com/research_articles/Jeppesen-et-al(2003).pdf

4. Rebaudioside A Potently Stimulates Insulin Secretion and eliminates the risk of hypoglycaemia Conclusion: Rebaudioside A potently stimulates the insulin secretion. Interestingly, rebaudioside A doesn’t cause a stimulation of insulin release at near-normal glucose levels, which is likely to reduce or eliminate the risk of hypoglycaemia.

http://www.steviainfo.com/research_articles/Abudula-et-al(2004).pdf

5. Molecules of Interest 2003

Conclusion: Stevia is safe when used as a sweetener. It is suited for both diabetics, and Phenylketoneneurics, as well as for obese persons intending to lose weight by avoiding sugar supplements in the diet. No allergic reactions seem to exist.

http://www.steviainfo.com/research_articles/Geuns(2003).pdf

6. Inhibitory Effect of Stevioside on Tumor Promotion

Conclusion: The pharmacological activities of Stevioside and related compounds can be summarized as follows:

1) Sweetener in diet for diabetes patients; 2) no abnormalities 3) has an anti-inflammatory effect and 4) has an

anti-tumor promoting effect.

http://www.steviainfo.com/research_articles/Geuns(2003).pdf

7. Stevia rebaudiana Bertoni does not produce female reproductive toxic effect

Conclusion: The water-based extracts of Stevia leaf and Stevioside do not pose any significant female reproductive toxicity or complication in pregnancy. In other words, this study exonerates Stevia and the sweetener Stevioside obtained from it of any female reproductive toxic or teratogenic effect.

http://srbce.org/jer2008/dileepkumar.pdf

8. Metabolism of Stevioside and Rebaudioside A from Stevia rebaudiana Extracts by Human Microflora

Conclusion: In this study, the human intestinal microflora was not able to degrade steviol. Furthermore, Stevioside and rebaudioside A did not significantly influence the composition of fecal cultures; among the selected intestinal groups, bactericides were the most efficient in hydrolysing Stevia sweeteners to steviol.

http://www.steviainfo.com/research_articles/Gardana-et-al-(2003).pdf

9. Efficacy and Tolerability of Oral Stevioside in Patients with Mild Essential Hypertension

Conclusion: In this 2 year study in Chinese patients with mild hypertension, oral Stevioside significantly decreased Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) compared with placebo. Quality of Life was improved, and no significant adverse effects were noted.

http://www.steviainfo.com/research_articles/Hsieh-et-al-(2003).pdf

10. Interactions of Stevioside and Steviol with Renal Organic Anion Transporters in S2 Cells and Mouse Renal Cortical Slices 2005

Conclusion: Stevioside has no interaction with human or mouse Organic Anion Transporters (OATs). In contrast, steviol interacts directly with human OATs, suggesting that the inhibition of OAT-mediated transport by steviol could alter renal drug clearance.

http://www.steviainfo.com/research_articles/Srimaroeng-et-al-(2005)-2.pdf

11. Effect of Steviol on para-Aminohippurate Transport by Isolated Perfused Rabbit Renal Proximal Tubule 2001

Conclusion: Kinetic analyses indicated that steviol can competitively inhibit PAH transport at the basolateral membrane. The present study clearly showed that steviol can have a direct inhibitory effect on renal tubular transport by competitive binding with organic anion transporter.

http://www.steviainfo.com/research_articles/Chatsudthipong-et-al-(2001).pdf

12. The Effect of Stevioside on Blood Pressure and Plasma Catecholamines in Spontaneously Hypertensive Rats 1998

Conclusion: The study shows that Stevioside given intravenously to conscious Spontaneously Hypertensive Rats (SHR) was effective in blood pressure reduction and there was no change in serum catechlamines anaesthetized

animal with this natural compound.

http://www.steviainfo.com/research_articles/Chan-et-al-(2000).pdf

13. No damage to DNA

Conclusion: All studies showed negative responses, proving that Stevia extract and steviol do not have DNA-damaging activity in cultured cells and mouse organs.

http://www.ncbi.nlm.nih.gov/pubmed/12533916

14. A critical review of the genetic toxicity of steviol and steviol glycosides

Conclusion: Neither Stevioside nor steviol-induced clastogenic effects at extremely high dose levels in vivo. Application of a Weight-of-Evidence approach to assess the genetic toxicology database concludes that these

substances do not pose a risk of genetic damage following human consumption.

http://www.ncbi.nlm.nih.gov/pubmed/18556105?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed

_ResultsPanel.PubmedDiscoveryPanel.Pubmed_Discovery_RA&;linkpos=5&;log$=relatedreviews&;logdb=pubm

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